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Homogeneous Immunoassays—Therapeutic Drug Monitoring
QMS®—Latex Enhanced Immunoturbidimetric Assays
Tobramycin Assay System
The TOBRAMYCIN Assay System is intended for the quantitative determination of total tobramycin in serum for therapeutic drug monitoring.
Tobramycin is an aminoglycoside antibiotic, with properties similar to gentamicin, which is used to treat resistant and serious infections due to gram negative bacteria.1-4 Tobramycin is particularly effective against Pseudomonas aeruginosa infections and is used to treat pneumonia and bacteremia caused by this organism.1-2 The aminoglycosides appear to inhibit bacterial protein synthesis by specifically binding to the 30 S ribosomal subunit.3-5
Tobramycin is routinely administered intravenously or intramuscularly, is reapidly dispersed into extracellular fluid, does not cross most cell membranes, and is essentially unbound to serum proteins.3 As with other aminoglycosides, tobramycin is potentially ototoxic and nephrotoxic.1-10 In patients with normal renal function, tobramycin is rapidly excreted, primarily by glomerular filtration, with an elimination half-life of approximately three hours.3,10,11 The use of tobramycin in renal patients must be carefully monitored. Measurement of serum levels is necessary to prevent toxicity and inadequate dosing, due to wide individual variation in the elimination and distribution of tobramycin.3,4 Immunoassays using a fluorescence polarization technique for tobramycin have been published.12,13
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