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Homogeneous Immunoassays—Therapeutic Drug Monitoring
QMS®—Latex Enhanced Immunoturbidimetric Assays
Phenobarbital Assay System
The PHENOBARBITAL Assay System is intended for the quantitative determination of total phenobarbital in serum for therapeutic drug monitoring.
Phenobarbital is a barbiturate that has been used extensively as an anticonvulsant since 1912.1,2 it is generally administered to epileptic patients in oral doses, often in conjunction with other anticonvulsant drugs. Oral absorption of Phenobarbital is complete but slow, with peak plasma concentrations reached several hours after intake.1 Approximately 50% of the drug is bound to plasma proteins, with binding to a similar extent in tissue. After dosing, 25-50% is excreted unchanged in the urine.3 The remainder is metabolized almost exclusively in the liver to inactive metabolites, mainly the parahydroxyphenyl and the N-glucoside derivatives.1,4,5
Monitoring serum concentrations of Phenobarbital has been recommended for effective patient therapy because of phenobarbital’s narrow therapeutic index and wide interindividual variability in the rate of metabolism and clearance.6,7
Immunoassays using a fluorescence polarization technique for phenobarbital have been published.8,9
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